Publications

Phyo W. Win, Julia Nguyen, Amanda L. Morin, Charles E. Newcomb, Shiva M. Singh, Noha Gomaa, Christina A. Castellani (2024). Simultaneous assessment of mitochondrial DNA copy number and nuclear epigenetic age towards predictive models of development and aging. BMC Research Notes.

Julia Nguyen, Quinn Le, Phyo W. Win, Kathleen A. Hill, Shiva M. Singh, Christina A. Castellani (2023). Decoding mitochondrial-nuclear (epi)genome interactions: the emerging role of ncRNAs. Epigenomics.

Phyo W. Win, Shiva M. Singh, Christina A. Castellani (2023). Mitochondrial DNA Copy Number and Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia. Twin Research and Human Genetics.

Amanda L. Morin, Phyo W. Win, Angela Z. Lin, Christina A. Castellani (2022).  Mitochondrial genomic integrity and the nuclear epigenome in health and disease. Frontiers in Endocrinology.

Shiva M. Singh, Phyo W. Win, Christina A. Castellani (2022).  Complementary approaches involving monozygotic twins and single neuron genomics support postzygotic somatic mutations in schizophrenia. Schizophrenia Research.

Eric A. Kirk, Christina A. Castellani, Timothy J. Doherty, Charles L. Rice, Shiva M. Singh (2022).  Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors. Physiological Genomics.

Ryan J. Longchamps, Stephanie Y. Yang, Christina A. Castellani, Wen Shi, John A. Lane, Megan L. Grove, Traci M. Bartz, Chloé Sarnowski, Kimberely Burrows, Anna L. Guyatt, Tom R. Gaunt, Tim Kacprowski, Jingyun Yang, P.L. De Jager, L. Yu, CHARGE Aging and Longevity Group, Omitted 31 Authors, Jerome I. Rotter, Eric Boerwinkle, Nathan Pankratz, Dan E. Arking (2022). Genome-wide analysis of mitochondrial DNA copy number reveals multiple loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation. Human Genetics.

Penglong Wang, Christina A. Castellani, Jie Yao, Tianxiao Huan, Lawrence F. Bielak, Wei Zhao, Jeffrey Haessler, Joehanes Roby, Xianbang Sun, Xiuqing Guo, Ryan J. Longchamps, JoAnn E. Manson, Megan L. Grove, Jan Bressler, Kent D. Taylor, Tuuli Lappalainen, Silva Kasela, David J. Van Den Berg, Lifang Hou, Alexander Reiner, Yongmei Liu (2022). Epigenome-wide association study of mitochondrial genome copy number. Human Molecular Genetics.

Nikhil S. Patil, Biao Feng, Zhaoliang Su, Christina A. Castellani, Subrata Chakrabarti (2021). Circular RNA mediated gene regulation in chronic diabetic complications. Scientific Reports.

Stephanie Y. Yang, Christina A. Castellani, Ryan J. Longchamps, Vamsee K. Pillalamarri, Brian O'Rourke, Eliseo Guallar, Dan E. Arking (2021). Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease. Genome Research.

Christina A. Castellani, Ryan J. Longchamps, Jason A. Sumpter, Charles E. Newcomb, John A. Lane, Megan L. Grove, Jan Bressler, Jennifer A. Brody, James S. Floyd, Traci M. Bartz, Kent D. Taylor, Penglong Wang, Adrienne Tin, Josef Coresh, James S. Pankow, Myriam Fornage, Eliseo Guallar, Brian O'Rourke, Omitted 5 Authors, Dan E. Arking (2020). Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs. Genome Medicine.

Bonnie L. J. Alberry, Christina A. Castellani, Shiva M. Singh (2020). Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder. Journal of Neurodevelopmental Disorders.

Di Zhao, Traci M. Bartz, Nona Sotoodehnia, Wendy S. Post, Susan R. Heckbert, Alvaro Alonso, Ryan J. Longchamps, Christina A. Castellani, Yun Soo Hong, Jerome I. Rotter, Henry J. Lin, Brian O'Rourke, Nathan Pankratz, John A. Lane, Stephanie Y. Yang, Eliseo Guallar, Dan E. Arking (2020). Mitochondrial DNA copy number and incident atrial fibrillation. BMC Medicine.

Christina A. Castellani, Ryan J. Longchamps, Jing Sun, Eliseo Guallar, Dan E. Arking (2020). Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease. Mitochondrion.

Yun Soo Hong, Ryan J. Longchamps, Di Zhao, Christina A. Castellani, Laura R. Loehr, Patricia P. Chang, Kunihiro Matsushita, Megan L. Grove, Eric Boerwinkle, Dan E. Arking, Eliseo Guallar (2020). Mitochondrial DNA Copy Number and Incident Heart Failure. Circulation.

Christina A. Castellani, Dan E. Arking (2020). High-Risk, High-Reward Genetics in ASD. Neuron.

Ryan J. Longchamps, Christina A. Castellani, Stephanie Y. Yang, Charles E. Newcomb, Jason A. Sumpter, John Lane, Megan L. Grove, Eliseo Guallar, Nathan Pankratz, Kent D. Taylor, Jerome I. Rotter, Eric Boerwinkle, Dan E. Arking (2020). Evaluation of mitochondrial DNA copy number estimation techniques. PLoS One.

Shiva M. Singh, Christina A. Castellani, Kathleen A. Hill (2020). Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of Schizophrenia. Frontiers in Psychiatry.

Jing Sun, Ryan J. Longchamps, Damani A. Piggott, Christina A. Castellani, Jason A. Sumpter, Todd T. Brown, Shruti H. Mehta, Dan E. Arking, Gregory D. Kirk (2018). Association Between HIV Infection and Mitochondrial DNA Copy Number in Peripheral Blood: A Population-Based, Prospective Cohort Study. The Journal of Infectious Diseases.

Yiyi Zhang, Eliseo Guallar, Foram N. Ashar, Ryan J. Longchamps, Christina A. Castellani, John Lane, Megan L. Grove, Josef Coresh, Nona Sotoodehnia, Leonard Ilkhanoff, Eric Boerwinkle, Nathan Pankratz, Dan E. Arking (2017). Association between mitochondrial DNA copy number and sudden cardiac death: findings from the Atherosclerosis Risk in Communities study (ARIC). European Heart Journal.

Christina A. Castellani, Melkaye G. Melka, Jane L. Gui, Anthony J. Gallo, Richard L. O'Reilly, Shiva M. Singh (2017). Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia. Clinical and Translational Medicine.

Emma Reble, Christina A. Castellani, Melkaye G. Melka, Richard O'Reilly, Shiva M. Singh (2017). VarScan2 analysis of de novo variants in monozygotic twins discordant for schizophrenia. Psychiatric Genetics.

Melkaye G. Melka, Christina A. Castellani, Shiva M. Singh (2016). Changes in DNA Sequence and Methylation Contribute to the Predisposition of Schizophrenia: Toward an Epigenetic Therapy. Schizophrenia Treatment - The New Facets.

Eric J. Chater-Diehl, Benjamin I. Laufer, Christina A. Castellani, Bonnie L. Alberry, Shiva M. Singh (2016). Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. PLoS One.

Christina A. Castellani, Melkaye G. Melka, Jane L. Gui, Richard L. O'Reilly, Shiva M. Singh (2015). Integration of DNA sequence and DNA methylation changes in monozygotic twin pairs discordant for schizophrenia. Schizophrenia Research.

Benjamin I. Laufer, Joachim Kapalanga, Christina A. Castellani, Eric J. Diehl, Liying Yan, Shiva M. Singh (2015). Associative DNA methylation changes in children with prenatal alcohol exposure. Epigenomics.

Melkaye G. Melka, Christina A. Castellani, Richard L. O'Reilly, Shiva M. Singh (2015). Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophrenia. Journal of Molecular Psychiatry.

Christina A. Castellani, Benjamin I. Laufer, Melkaye G. Melka, Eric J. Diehl, Richard L. O'Reilly, Shiva M. Singh (2015). DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. BMC Medical Genomics.

Christina A. Castellani, Melkaye G. Melka, Eric J. Diehl, Benjamin I. Laufer, Richard L. O'Reilly, Shiva M. Singh (2015). DNA methylation in psychosis: insights into etiology and treatment. Future Medicine.

Christina A. Castellani, Melkaye G. Melka, Andrea E. Wishart, M. Elizabeth O. Locke, Zain Awamleh, Richard L. O'Reilly, Shiva M. Singh (2014). Biological relevance of CNV calling methods using familial relatedness including monozygotic twins. BMC Bioinformatics.

Melkaye G. Melka, Benjamin I. Laufer, Patrick McDonald, Christina A. Castellani, Nagalingam Rajakumar, Richard L. O'Reilly, Shiva M. Singh (2014). The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum. Clinical Epigenetics.

Christina A. Castellani, Zain Awamleh, Melkaye G. Melka, Richard L. O'Reilly, Shiva M. Singh (2014). Copy Number Variation Distribution in Six Monozygotic Twin Pairs Discordant for Schizophrenia. Twin Research and Human Genetics.

Melkaye G. Melka, Christina A. Castellani, Nagalingam Rajakumar, Richard L. O'Reilly, Shiva M. Singh (2014). Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. BMC Neuroscience.

Kiran H. B. Kumar, Christina A. Castellani, Sujit Maiti, Richard L. O'Reilly, Shiva M. Singh (2013). Search for missing schizophrenia genes will require a new developmental neurogenomic perspective. Journal of Genetics.

Melkaye G. Melka, Christina A. Castellani, Benjamin I. Laufer, Raj N. Rajakumar, Richard L. O'Reilly, Shiva M. Singh (2013). Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosis. Journal of Molecular Psychiatry.

Kiran H.B. Kumar, Sujit Maiti, Christina A. Castellani, Richard L. O'Reilly, Shiva M. Singh (2013). A novel deletion cluster at 13q14.2-q21.33 in an 80-year man with late onset leukemia: Clinical and molecular findings. Indian Journal of Human Genetics.

Brandon Abbs, Rashmin M. Achalia, Adegoke O. Adelufosi, Ahmet Yiǧit Aktener, Natalie J. Beveridge, Savita G. Bhakta, Rachael K. Blackman, Emre Bora, M. S. Byun, Maurice Cabanis, Ricardo Carrion, Christina A. Castellani, Tze Jen Chow, M. Dmitrzak-Weglarz, Charlotte Gayer-Anderson, Felipe V. Gomes, Kristen Haut, Hiroaki Hori, Joshua T. Kantrowitz, Taishiro Kishimoto, Omitted 17 Authors (2012). The 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy: Summaries of oral sessions. Schizophrenia Research.

Sujit Maiti, Kiran H.B. Gowda Kumar, Christina A. Castellani, Richard L. O'Reilly, Shiva M. Singh (2011). Ontogenetic De Novo Copy Number Variations (CNVs) as a Source of Genetic Individuality: Studies on Two Families with MZD Twins for Schizophrenia. PLoS One.

Shiva M. Singh, Christina Castellani, Richard O'Reilly (2010). Autism meets schizophrenia via cadherin pathway. Schizophrenia Research.

Shiva M. Singh, Christina A. Castellani, Richard L. O'Reilly (2009). Copy number variation showers in schizophrenia: an emerging hypothesis. Molecular Psychiatry.