Publications

SELECTED PUBLICATIONS

Eric A. Kirk, Christina A. Castellani, Timothy J. Doherty, Charles L. Rice, Shiva M. Singh (2022).  Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensorsPhysiological Genomics.

Ryan J. Longchamps, Stephanie Y. Yang, Christina A. Castellani, Wen Shi, John A. Lane, Megan L. Grove, Traci M. Bartz, Chloé Sarnowski, Kimberely Burrows, Anna L. Guyatt, Tom R. Gaunt, Tim Kacprowski, Jingyun Yang, P.L. De Jager, L. Yu, CHARGE Aging and Longevity Group, Omitted 31 Authors, Jerome I. Rotter, Eric Boerwinkle, Nathan Pankratz, Dan E. Arking (2022). Genome-wide analysis of mitochondrial DNA copy number reveals multiple loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferationHuman Genetics.

Penglong Wang, Christina A. Castellani, Jie Yao, Tianxiao Huan, Lawrence F. Bielak, Wei Zhao, Jeffrey Haessler, Joehanes Roby, Xianbang Sun, Xiuqing Guo, Ryan J. Longchamps, JoAnn E. Manson, Megan L. Grove, Jan Bressler, Kent D. Taylor, Tuuli Lappalainen, Silva Kasela, David J. Van Den Berg, Lifang Hou, Alexander Reiner, Yongmei Liu (2022). Epigenome-wide association study of mitochondrial genome copy number. Human Molecular Genetics.

Nikhil S. Patil, Biao Feng, Zhaoliang Su, Christina A. Castellani, Subrata Chakrabarti (2021). Circular RNA mediated gene regulation in chronic diabetic complicationsScientific Reports.

Stephanie Y. Yang, Christina A. Castellani, Ryan J. Longchamps, Vamsee K. Pillalamarri, Brian O'Rourke, Eliseo Guallar, Dan E. Arking (2021). Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease. Genome Research.

Christina A. Castellani, Ryan J. Longchamps, Jason A. Sumpter, Charles E. Newcomb, John A. Lane, Megan L. Grove, Jan Bressler, Jennifer A. Brody, James S. Floyd, Traci M. Bartz, Kent D. Taylor, Penglong Wang, Adrienne Tin, Josef Coresh, James S. Pankow, Myriam Fornage, Eliseo Guallar, Brian O'Rourke, Omitted 5 Authors, Dan E. Arking (2020). Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGsGenome Medicine.

Bonnie L. J. Alberry, Christina A. Castellani, Shiva M. Singh (2020). Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorderJournal of Neurodevelopmental Disorders.

Di Zhao, Traci M. Bartz, Nona Sotoodehnia, Wendy S. Post, Susan R. Heckbert, Alvaro Alonso, Ryan J. Longchamps, Christina A. Castellani, Yun Soo Hong, Jerome I. Rotter, Henry J. Lin, Brian O'Rourke, Nathan Pankratz, John A. Lane, Stephanie Y. Yang, Eliseo Guallar, Dan E. Arking (2020). Mitochondrial DNA copy number and incident atrial fibrillationBMC Medicine.

Christina A. Castellani, Ryan J. Longchamps, Jing Sun, Eliseo Guallar, Dan E. Arking (2020). Thinking outside the nucleus: Mitochondrial DNA copy number in health and diseaseMitochondrion.

Yun Soo Hong, Ryan J. Longchamps, Di Zhao, Christina A. Castellani, Laura R. Loehr, Patricia P. Chang, Kunihiro Matsushita, Megan L. Grove, Eric Boerwinkle, Dan E. Arking, Eliseo Guallar (2020). Mitochondrial DNA Copy Number and Incident Heart FailureCirculation.

Christina A. Castellani, Dan E. Arking (2020). High-Risk, High-Reward Genetics in ASD. Neuron.

Ryan J. Longchamps, Christina A. Castellani, Stephanie Y. Yang, Charles E. Newcomb, Jason A. Sumpter, John Lane, Megan L. Grove, Eliseo Guallar, Nathan Pankratz, Kent D. Taylor, Jerome I. Rotter, Eric Boerwinkle, Dan E. Arking (2020). Evaluation of mitochondrial DNA copy number estimation techniques. PLoS One.

Shiva M. Singh, Christina A. Castellani, Kathleen A. Hill (2020). Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of SchizophreniaFrontiers in Psychiatry.

Jing Sun, Ryan J. Longchamps, Damani A. Piggott, Christina A. Castellani, Jason A. Sumpter, Todd T. Brown, Shruti H. Mehta, Dan E. Arking, Gregory D. Kirk (2018). Association Between HIV Infection and Mitochondrial DNA Copy Number in Peripheral Blood: A Population-Based, Prospective Cohort StudyThe Journal of Infectious Diseases.

Yiyi Zhang, Eliseo Guallar, Foram N. Ashar, Ryan J. Longchamps, Christina A. Castellani, John Lane, Megan L. Grove, Josef Coresh, Nona Sotoodehnia, Leonard Ilkhanoff, Eric Boerwinkle, Nathan Pankratz, Dan E. Arking (2017). Association between mitochondrial DNA copy number and sudden cardiac death: findings from the Atherosclerosis Risk in Communities study (ARIC). European Heart Journal.

Christina A. Castellani, Melkaye G. Melka, Jane L. Gui, Anthony J. Gallo, Richard L. O'Reilly, Shiva M. Singh (2017). Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophreniaClinical and Translational Medicine.

Emma Reble, Christina A. Castellani, Melkaye G. Melka, Richard O'Reilly, Shiva M. Singh (2017). VarScan2 analysis of de novo variants in monozygotic twins discordant for schizophreniaPsychiatric Genetics.

Melkaye G. Melka, Christina A. Castellani, Shiva M. Singh (2016). Changes in DNA Sequence and Methylation Contribute to the Predisposition of Schizophrenia: Toward an Epigenetic TherapySchizophrenia Treatment - The New Facets.

Eric J. Chater-Diehl, Benjamin I. Laufer, Christina A. Castellani, Bonnie L. Alberry, Shiva M. Singh (2016). Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. PLoS One.

Christina A. Castellani, Melkaye G. Melka, Jane L. Gui, Richard L. O'Reilly, Shiva M. Singh (2015). Integration of DNA sequence and DNA methylation changes in monozygotic twin pairs discordant for schizophreniaSchizophrenia Research.

Benjamin I. Laufer, Joachim Kapalanga, Christina A. Castellani, Eric J. Diehl, Liying Yan, Shiva M. Singh (2015). Associative DNA methylation changes in children with prenatal alcohol exposureEpigenomics.

Melkaye G. Melka, Christina A. Castellani, Richard L. O'Reilly, Shiva M. Singh (2015). Insights into the origin of DNA methylation differences between monozygotic twins discordant for schizophreniaJournal of Molecular Psychiatry.

Christina A. Castellani, Benjamin I. Laufer, Melkaye G. Melka, Eric J. Diehl, Richard L. O'Reilly, Shiva M. Singh (2015). DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networksBMC Medical Genomics.

Christina A. Castellani, Melkaye G. Melka, Eric J. Diehl, Benjamin I. Laufer, Richard L. O'Reilly, Shiva M. Singh (2015). DNA methylation in psychosis: insights into etiology and treatmentFuture Medicine.

Christina A. Castellani, Melkaye G. Melka, Andrea E. Wishart, M. Elizabeth O. Locke, Zain Awamleh, Richard L. O'Reilly, Shiva M. Singh (2014). Biological relevance of CNV calling methods using familial relatedness including monozygotic twinsBMC Bioinformatics.

Melkaye G. Melka, Benjamin I. Laufer, Patrick McDonald, Christina A. Castellani, Nagalingam Rajakumar, Richard L. O'Reilly, Shiva M. Singh (2014). The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellumClinical Epigenetics.

Christina A. Castellani, Zain Awamleh, Melkaye G. Melka, Richard L. O'Reilly, Shiva M. Singh (2014). Copy Number Variation Distribution in Six Monozygotic Twin Pairs Discordant for SchizophreniaTwin Research and Human Genetics.

Melkaye G. Melka, Christina A. Castellani, Nagalingam Rajakumar, Richard L. O'Reilly, Shiva M. Singh (2014). Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosisBMC Neuroscience.

Kiran H. B. Kumar, Christina A. Castellani, Sujit Maiti, Richard L. O'Reilly, Shiva M. Singh (2013). Search for missing schizophrenia genes will require a new developmental neurogenomic perspectiveJournal of Genetics.

Melkaye G. Melka, Christina A. Castellani, Benjamin I. Laufer, Raj N. Rajakumar, Richard L. O'Reilly, Shiva M. Singh (2013). Olanzapine induced DNA methylation changes support the dopamine hypothesis of psychosisJournal of Molecular Psychiatry.

Kiran H.B. Kumar, Sujit Maiti, Christina A. Castellani, Richard L. O'Reilly, Shiva M. Singh (2013). A novel deletion cluster at 13q14.2-q21.33 in an 80-year man with late onset leukemia: Clinical and molecular findingsIndian Journal of Human Genetics.

Brandon Abbs, Rashmin M. Achalia, Adegoke O. Adelufosi, Ahmet Yiǧit Aktener, Natalie J. Beveridge, Savita G. Bhakta, Rachael K. Blackman, Emre Bora, M. S. Byun, Maurice Cabanis, Ricardo Carrion, Christina A. Castellani, Tze Jen Chow, M. Dmitrzak-Weglarz, Charlotte Gayer-Anderson, Felipe V. Gomes, Kristen Haut, Hiroaki Hori, Joshua T. Kantrowitz, Taishiro Kishimoto, Omitted 17 Authors (2012). The 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy: Summaries of oral sessionsSchizophrenia Research.

Sujit Maiti, Kiran H.B. Gowda Kumar, Christina A. Castellani, Richard L. O'Reilly, Shiva M. Singh (2011). Ontogenetic De Novo Copy Number Variations (CNVs) as a Source of Genetic Individuality: Studies on Two Families with MZD Twins for SchizophreniaPLoS One.

Shiva M. Singh, Christina Castellani, Richard O'Reilly (2010). Autism meets schizophrenia via cadherin pathwaySchizophrenia Research.

Shiva M. Singh, Christina A. Castellani, Richard L. O'Reilly (2009). Copy number variation showers in schizophrenia: an emerging hypothesisMolecular Psychiatry.